Delayed Reactions

Delayed hemolytic transfusion reactions.

Delayed hemolytic transfusion reactions continue to occur in spite of the use of all of the currently available techniques of antibody detection. Both low titers of the antibodies and dosage effects appear to contribute to the failure of detection. A rapid anamnestic response can occur with transfusion of the appropriate antigen. The clinical as well as the laboratory presentation of delayed he...

Cell Reactions in Delayed Hypersensitivity

Delayed hypersensitivity reactions to corticosteroids.

BACKGROUND Corticosteroids (CS) are widely used in the treatment of asthma, allergic disorders and other immunological diseases due to their anti-inflammatory and immunosuppressive properties. Physicians seldom suspect them of causing allergic reactions. However, more and more cases of hypersensitivity reactions to CS have been described. Reports of delayed allergic reactions to CS in patients ...

Delayed reactions to bouillon medium of tuberculin.

In testing persons who are negative to weak dilutions of old tuberculin, it is frequently noted that a disproportionately large reaction may occur with the stronger dilutions. The suspicion has been voiced that these reactions to strong concentrations of old tuberculin may be non-specific. The problem is of special importance in testing children prior to BCG administration. Are those who react ...

Allergic and nonallergic delayed infusion reactions during natalizumab therapy.

BACKGROUND The monoclonal antibody natalizumab is a novel therapeutic option in the treatment of relapsing forms of multiple sclerosis. In general, therapy with natalizumab is well tolerated. Allergic reactions and acute infusion reactions typically occur during or shortly after infusion, with a peak at the second infusion. Delayed infusion reactions resembling serum sickness-type reactions (ty...